Males exposed to mild analgesics in utero may be at increased risk for

The World in Medicine
JAMA. 2010;304(23):2582. doi: 10.1001/jama.2010.1801
Painkillers in Pregnancy
1. Tracy Hampton, PhD
Since this article does not have an abstract, we have provided the first 150
words of the full text.

Males exposed to mild analgesics in utero may be at increased risk for
developing reproductive disorders, according to research
conducted in women from Denmark and Finland (Kristensen DM et al. Hum Reprod.
doi: 10.1093/humrep/deq323 [published
online ahead of print November 8, 2010]).

The prospective study included 2297 Danish and Finnish pregnant women who
answered questions about their use of mild analgesics—such as
paracetamol (acetaminophen), aspirin, and ibuprofen—during pregnancy. About
64.3% of the Danish mothers with sons born with congenital
cryptorchidism, or undescended testes, reported the use of mild analgesics
during pregnancy compared with 55.5% of mothers with healthy
boys. Mothers reporting use of more than one specific analgesic had a 7-fold
increased risk of giving birth to sons with cryptorchidism;
use of any analgesic during the second trimester or for longer than 2 weeks
more than doubled the risk of cryptorchidism. The association
was not found in the Finnish …

Subscription required for sign in
http://jama.ama-assn.org/content/304/23/2582.3.full